Our Neuro Expertise

ANEWCRO specializes in advanced central nervous system (CNS) drug delivery techniques, offering a range of precise administration routes for test articles. These include intrathecal (IT), intracisternal magna, intracerebroventricular (ICV), and intraparenchymal delivery methods, as well as cerebrospinal fluid (CSF) porting for both acute and long-term studies. These administration routes enable targeted delivery of therapeutics directly into the CNS, bypassing the blood-brain barrier (BBB) and enhancing drug bioavailability.

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The intrathecal (IT) route involves direct administration of test articles into the subarachnoid space of the spinal cord, allowing for rapid drug distribution throughout the cerebrospinal fluid. This method is particularly useful for assessing neuroactive compounds, gene therapies, and biologics intended to treat neurodegenerative diseases, chronic pain, and spinal cord injuries.

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Intracisternal magna administration delivers the test article into the cisterna magna, a cerebrospinal fluid-filled space located at the base of the brainstem. This technique is commonly employed in studies requiring extensive CSF circulation and diffusion of the compound within the cranial subarachnoid space, facilitating widespread CNS exposure.

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Intracerebroventricular (ICV) dosing involves direct injection of the test article into the brain’s ventricular system, typically targeting the lateral or fourth ventricles. This approach allows for efficient drug distribution via the CSF and is frequently utilized in studies of neurotrophic factors, enzyme replacement therapies, and treatments for lysosomal storage disorders.

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Intraparenchymal administration enables highly localized drug delivery directly into specific brain regions. This method is particularly beneficial for studies investigating treatments for focal neurological conditions such as glioblastoma, Parkinson’s disease, or epilepsy. Using advanced stereotaxic guidance, ANEWCRO ensures precise placement of the injection to maximize therapeutic effect while minimizing off-target exposure.

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For longitudinal studies requiring repeated administration or monitoring, ANEWCRO offers cerebrospinal fluid (CSF) porting solutions. Implanted CSF ports provide a minimally invasive, reliable method for repeated drug delivery and serial CSF sampling over extended study durations, reducing stress and procedural burden on study subjects.

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CSF sampling can be performed via direct intrathecal access or through a lumbar port, allowing for serial collections without repeated needle punctures. These techniques facilitate pharmacokinetic (PK) and pharmacodynamic (PD) profiling, biomarker analysis, and assessment of drug penetration into the CNS. Serial CSF collections are particularly valuable in studies evaluating drug clearance, target engagement, and disease progression biomarkers.

By integrating cutting-edge CNS drug administration and sampling methodologies, ANEWCRO provides researchers with unparalleled precision and flexibility in studying the effects of therapeutics within the central nervous system. Our extensive expertise ensures high-quality data collection, supporting the development of novel treatments for a wide range of neurological disorders.

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